FOLFIRINOX goes adjuvant

FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer.

BACKGROUND Data are lacking on the efficacy and safety of a combination chemotherapy regimen consisting of oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) as compared with gemcitabine as first-line therapy in patients with metastatic pancreatic cancer. METHODS We randomly assigned 342 patients with an Eastern Cooperative Oncology Group performance status score of 0 or 1 (on...

As iron goes, so goes disease?

The brain iron overload disorders, collectively known as neurodegeneration with brain iron accumulation (NBIA), would seem to be tantalizing targets for chelation therapy. Efforts to lower brain iron in these disorders date back to the 1960s with deferoxamine mesylate, but systemic iron depletion limited its use. With the advent of chelators better able to specifically relieve central nervous s...

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Motivated by recent developments in solid electrolytes based on lithium phosphorous oxynitride (LiPON) materials, we carried out computer simulations in order to develop an understanding of the detailed mechanisms of ionic transport. Starting with crystalline Li3PO4, we investigated some possible structures of isolated defects associated with extrinsic Li ion vacancies and interstitials. In par...

Anything Goes

Representing OT hierarchies in terms of weighted sums of violations requires in the general case exponential growth of weights; and any such weight system will only work for finite fragments of grammars in which the quantity of violations incurred by optima does not grow without bound (typically, those fragments in which input size is bounded). This conclusion is based on a worst-case analysis,...

Cantor goes